The archaeological collection is housed in a traditional Symi mansion of Yianneskis family which was given as an endowment to N. K. Pharmakidis, tradesman and vice consul on Symi. It was given to the Greek state by Ariadne B. Pharmakidis and Sevasti N.Farmakidi. In the exhibition you will see a representation of the interior of a Symi house with its dining and living room (furniture, crockery, paintings and photographs of the period), as well as traditional local costumes.

The museum houses the following collections:

In the center of the monastic complex of Panormitis you will see the Byzantine Museum. Here you will also see bottles-offerings that faithful followers left in the sea and hoped they would reach the monastery. One of the most characteristic ones is what came from Leipzig in 1998, with oil, wax, incense and names "for commemoration." There are also items dating back to 1930, a carved canopy of an epitaph of the 18th century, swords and guns and a clock of 1896.

This is a monastery complex with cells, a bank, hostels, a kitchen, a library, a sacristy, a cemetery, a museum, reception rooms and a pebbled courtyard. The monastery exists from  the period of the Knights. It was destroyed in the mid-18th century  and was rebuilt in 1783. The monastery played an important role in the revolution of 1821 by helping financially. The interior is covered with frescoes of brothers Karakosti (1783). The temple was built in the same year by Mastrodiakos Taliadouros, while the painting of Panormitis was made silver in 1724.